On one of our MOSS 2007 implementations, none of the sites (inlcuding Central Administration) were accessible. The error message returned was "HTTP 503 Service Unavailable".
The problem: Several updates had been downloaded and installed the night before. IPv6 (Internet Protocol version 6) had also been enabled.
The solution: Disable IPv6. This is a known issue - read more about the problem and the solution here.
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